Description

1-Piperidinecarboxylic Acid, 4-(4-Methoxyphenyl)-4-(2-Oxoethyl)-,1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound is a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting neurological and cardiovascular pathways. It is essential for research and development chemists and manufacturing organizations in the global pharmaceutical and fine chemical industries.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, especially for central nervous system (CNS) and cardiovascular therapeutics.
• API Synthesis: Used as a key chiral building block for constructing complex molecular architectures in Active Pharmaceutical Ingredient (API) manufacturing.
• Medicinal Chemistry Research: Enables the exploration of structure-activity relationships (SAR) in drug discovery programs for new chemical entities (NCEs).
• Process Development & Scale-up: Serves as a standard for optimizing synthetic routes from laboratory scale to pilot plant and commercial production.
• Contract Manufacturing (CMO/CDMO): Supplied to contract research and manufacturing organizations for custom synthesis projects requiring high-purity intermediates.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Item	Details
Product Name	1-Piperidinecarboxylic Acid, 4-(4-Methoxyphenyl)-4-(2-Oxoethyl)-,1,1-Dimethylethyl Ester
CAS No.	878130-45-1
Molecular Formula	C19H27NO4
Molecular Weight	333.43 g/mol
Synonyms	tert-Butyl 4-(4-methoxyphenyl)-4-(2-oxoethyl)piperidine-1-carboxylate; 4-(4-Methoxyphenyl)-4-(2-oxoethyl)piperidine-1-carboxylic acid tert-butyl ester; Boc-4-(4-Methoxyphenyl)-4-(2-oxoethyl)piperidine; N-Boc-4-(4-methoxyphenyl)-4-(2-oxoethyl)piperidine; 1-(tert-Butoxycarbonyl)-4-(4-methoxyphenyl)-4-(2-oxoethyl)piperidine; 878130-45-1; 4-(4-Methoxyphenyl)-4-(2-oxoethyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our production of 1-Piperidinecarboxylic Acid, 4-(4-Methoxyphenyl)-4-(2-Oxoethyl)-,1,1-Dimethylethyl Ester adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided for each shipment, supporting compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.