Description

(R)-tert-Butyl 4-(4-(6-Amino-5-(1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy)Pyridin-3-Yl)-1H-Pyrazol-1-Yl)Piperidine-1-Carboxylate is a high-purity, chiral organic intermediate of significant importance in modern pharmaceutical research and development. This compound is specifically designed for use as a key building block in the synthesis of targeted therapeutic agents, offering researchers precise control over molecular structure. It is primarily needed by pharmaceutical companies, biotechnology firms, and advanced contract research organizations (CROs) engaged in the discovery of novel small-molecule drugs.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of active pharmaceutical ingredients (APIs) for oncology and other therapeutic areas.
• Kinase Inhibitor Research: Serves as a core structural component in the development of novel protein kinase inhibitors.
• Preclinical Drug Development: Used in medicinal chemistry for lead optimization and structure-activity relationship (SAR) studies.
• Process Chemistry & Scale-up: Employed in route scouting and pilot-scale manufacturing of candidate drugs.
• Chemical Biology Probes: Utilized to create tool compounds for studying specific biological pathways and target validation.
• Custom Synthesis: A starting material for the contract manufacturing of specialized, high-value molecules for clinical trials.

Basic Information

Product Name	(R)-tert-Butyl 4-(4-(6-Amino-5-(1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy)Pyridin-3-Yl)-1H-Pyrazol-1-Yl)Piperidine-1-Carboxylate
CAS No.	877399-51-4
Molecular Formula	C28H31Cl2FN4O3
Molecular Weight	561.48 g/mol
Synonyms	1-Boc-4-[4-[6-Amino-5-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-3-pyridinyl]-1H-pyrazol-1-yl]piperidine; (R)-1-(tert-Butoxycarbonyl)-4-[4-[6-amino-5-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-pyridyl]pyrazol-1-yl]piperidine; BOC-Pyrazole-Piperidine Intermediate; Lorlatinib Intermediate (Key Chiral Fragment); PF-06463922 Intermediate (Chiral Precursor); 877399-51-4; ALK/ROS1 Inhibitor Intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is subjected to rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity suitable for pharmaceutical R&D. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment. We support development under cGMP guidelines for applications requiring regulatory filing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccant packs or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.