Description

(R)-5-Bromo-N,n-Bis-(tert-Butoxycarbonyl)-3-(1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy)Pyridin-2-Amine is a high-purity, advanced pharmaceutical intermediate characterized by its complex chiral structure. This compound is critical for the synthesis of targeted small molecule therapeutics, particularly in oncology and other specialized drug development pipelines. It is primarily utilized by pharmaceutical R&D organizations and contract manufacturing organizations (CMOs) engaged in the production of novel active pharmaceutical ingredients (APIs).

Application

• Key Intermediate in Targeted Oncology Drug Synthesis: Serves as a crucial building block for the development of kinase inhibitors and other targeted cancer therapies.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization processes.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for clinical and commercial API manufacturing.
• Pre-clinical and Clinical Trial Material Production: Essential for synthesizing high-quality drug candidates required for regulatory filings and clinical studies.
• Custom Synthesis Projects: Utilized by fine chemical suppliers for bespoke synthesis services catering to specific client molecular targets.

Basic Information

Product Name	(R)-5-Bromo-N,n-Bis-(tert-Butoxycarbonyl)-3-(1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy)Pyridin-2-Amine
CAS No.	877399-47-8
Molecular Formula	C23H26BrCl2FN2O5
Molecular Weight	584.28 g/mol
Synonyms	(R)-5-Bromo-N,N-bis(tert-butoxycarbonyl)-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-amine; 877399-47-8; (R)-5-Bromo-N,N-Bis-Boc-3-(1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy)Pyridin-2-Amine; (R)-5-Bromo-N,N-di-Boc-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-aminopyridine; 2-Pyridinamine, 5-bromo-N,N-bis[(1,1-dimethylethoxy)carbonyl]-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-, (2R)-; BOC-DebromoLorlatinib Intermediate (R-isomer); Lorlatinib Advanced Intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and cGMP manufacturing applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We implement analytical methods including HPLC, GC, NMR, and MS to verify identity and meet stringent client specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.