Description

(R)-3-(1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy)-2-Nitropyridine is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound matters for its role as a key building block in the development of targeted therapeutic agents, particularly kinase inhibitors. Pharmaceutical R&D and manufacturing companies need this precisely defined intermediate to ensure the stereochemical integrity and efficacy of their final active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of novel kinase inhibitors for oncology and inflammatory disease research.
• Active Pharmaceutical Ingredient (API) Development: Used in the research and process development of targeted small-molecule drugs.
• Chemical Biology & Proteomics: Serves as a tool compound or a scaffold for designing chemical probes to study specific biological pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical clients with custom synthesis and scale-up projects.
• Academic Research: Utilized in university and institutional labs for medicinal chemistry programs and methodology development.

Basic Information

Product Name	(R)-3-(1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy)-2-Nitropyridine
CAS No.	877397-70-1
Molecular Formula	C13H9Cl2FN2O3
Molecular Weight	331.13 g/mol
Synonyms	(R)-3-((1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine; (R)-3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine; 2-Nitropyridine, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-; 877397-70-1; (R)-3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-2-nitro-pyridine; (R)-3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-2-nitro pyridine
EINECS	Contact for details

Quality Control

Our (R)-3-(1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy)-2-Nitropyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D and cGMP manufacturing. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.