Description

tert-Butyl 4-(3,3-Difluoropyrrolidin-1-yl)piperidine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core with a difluoropyrrolidine substituent. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of new therapeutic agents, especially within the central nervous system (CNS) and oncology fields.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its unique difluorinated heterocyclic structure.
• API Development: Serves as a precursor in the multi-step synthesis of final active pharmaceutical ingredients for preclinical and clinical studies.
• Chemical Biology Probes: Employed in the development of tool compounds for investigating biological pathways and target validation.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	tert-Butyl 4-(3,3-Difluoropyrrolidin-1-yl)piperidine-1-carboxylate
CAS No.	877125-71-8
Molecular Formula	C14H24F2N2O2
Molecular Weight	290.35 g/mol
Synonyms	1-Boc-4-(3,3-difluoropyrrolidin-1-yl)piperidine; 1-(1,1-Dimethylethyl) 4-(3,3-difluoro-1-pyrrolidinyl)-1-piperidinecarboxylate; 4-(3,3-Difluoropyrrolidin-1-yl)piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-(3,3-difluoropyrrolidino)piperidine-1-carboxylate; 1-N-Boc-4-(3,3-difluoropyrrolidino)piperidine; BOC-4-(3,3-Difluoropyrrolidino)piperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(3,3-Difluoropyrrolidin-1-yl)piperidine-1-carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles suitable for pharmaceutical R&D applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat sources and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.