Description

2-Chloro-5-Fluoroisonicotinic Acid Methyl Ester is a high-purity fluorinated pyridine derivative, a crucial building block in modern synthetic chemistry. Its value lies in its role as a versatile intermediate for constructing complex molecules with tailored biological and material properties. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing new active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, leveraging the fluorine and chlorine substituents for enhanced bioactivity.
• Material Science Research: Serves as a precursor for functionalized ligands and organic frameworks in advanced material applications.
• Chemical Research & Development: A versatile building block for medicinal chemistry and process chemistry, enabling structure-activity relationship (SAR) studies.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke chemical synthesis projects.

Basic Information

Product Name	2-Chloro-5-Fluoroisonicotinic Acid Methyl Ester
CAS No.	876919-10-7
Molecular Formula	C7H5ClFNO2
Molecular Weight	189.57 g/mol
Synonyms	Methyl 2-Chloro-5-fluoroisonicotinate; 2-Chloro-5-fluoropyridine-4-carboxylic acid methyl ester; 4-Pyridinecarboxylic acid, 2-chloro-5-fluoro-, methyl ester; Methyl 2-chloro-5-fluoro-4-pyridinecarboxylate; 876919-10-7; 2-Chloro-5-fluoro-4-pyridinecarboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluoroisonicotinic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.