Description

1(2H)-Pyridinecarboxylic Acid, 4-(5-Bromo-4-Chloro-1H-Pyrrolo[2,3-B]Pyridin-2-Yl)-3,6-Dihydro-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant value for its role as a key building block in the synthesis of novel, targeted therapeutic agents. It is primarily required by research institutions and pharmaceutical companies engaged in the development of kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for oncology and antiviral research.
• Kinase Inhibitor Development: Serves as a core scaffold for constructing potent and selective kinase inhibitors due to its pyrrolopyridine moiety.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize drug candidate potency, selectivity, and pharmacokinetic properties.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the efficient, large-scale production of candidate drugs.
• Biochemical Tool Compound: Utilized in biochemical assays to study enzyme function and cellular signaling pathways.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the cGMP production of clinical trial materials.

Basic Information

Item	Details
Product Name	1(2H)-Pyridinecarboxylic Acid, 4-(5-Bromo-4-Chloro-1H-Pyrrolo[2,3-B]Pyridin-2-Yl)-3,6-Dihydro-, 1,1-Dimethylethyl Ester
CAS No.	876343-86-1
Molecular Formula	C17H17BrClN3O2
Molecular Weight	410.69 g/mol
Synonyms	tert-Butyl 4-(5-bromo-4-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate; 4-(5-Bromo-4-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylic acid 1,1-dimethylethyl ester; 876343-86-1; 5-Bromo-4-chloro-2-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-pyrrolo[2,3-b]pyridine tert-butyl ester
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the exacting standards required for pharmaceutical R&D and production. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and MS is supplied with each shipment. Our quality commitment aligns with ICH guidelines to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.