Description

5-Bromo-3-Iodo-1H-Pyrazolo[3,4-B]Pyridine is a high-value, multi-halogenated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in enabling the precise construction of complex molecular architectures, particularly in the development of novel pharmaceutical candidates and functional materials. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating targeted libraries and optimizing lead compounds. The CAS number for this substance is 875781-18-3.

Application

This versatile halogenated pyrazolopyridine serves as a critical intermediate in several high-tech research and development areas:

• Pharmaceutical Intermediate: Key building block for the synthesis of kinase inhibitors and other targeted therapeutic agents, leveraging its halogen handles for cross-coupling reactions.
• Agrochemical Research: Used in creating novel active ingredients for crop protection, where its heterocyclic core contributes to biological activity.
• Material Science Precursor: Employed in the development of organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Chemical Biology Probes: Acts as a scaffold for developing molecular probes and tools to study biological pathways and protein functions.
• Library Synthesis for Drug Discovery: Enables parallel and combinatorial chemistry approaches to rapidly generate diverse compound libraries for high-throughput screening.
• Catalyst Ligand Development: The nitrogen-rich structure can be modified to create novel ligands for transition metal catalysis.

Basic Information

Item	Detail
Product Name	5-Bromo-3-Iodo-1H-Pyrazolo[3,4-B]Pyridine
CAS No.	875781-18-3
Molecular Formula	C6H3BrIN3
Molecular Weight	323.92 g/mol
Synonyms	5-Bromo-3-iodo-1H-pyrazolo[3,4-b]pyridine; 1H-Pyrazolo[3,4-b]pyridine, 5-bromo-3-iodo-; 875781-18-3; 5-Br-3-I-1H-pyrazolo[3,4-b]pyridine; 3-Iodo-5-bromo-1H-pyrazolo[3,4-b]pyridine; Pyrazolo[3,4-b]pyridine, 5-bromo-3-iodo-1H-; SCHEMBL21842227
EINECS	Contact for details

Quality Control

Our 5-Bromo-3-Iodo-1H-Pyrazolo[3,4-B]Pyridine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. We provide comprehensive analytical data to support your development work. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every batch upon request. Our quality systems are designed to meet the stringent requirements of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended long-term storage at 2-8°C. The compound is light-sensitive and should be handled under an inert atmosphere when appropriate to ensure stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.