Description

5-Bromo-3-Iodo-1-Triisopropylsilanyl-1H-Pyrrolo[2,3-B]Pyridine is a high-purity, advanced pharmaceutical intermediate featuring a halogenated pyrrolopyridine core protected by a triisopropylsilyl (TIPS) group. This compound is specifically engineered for use in complex multi-step synthesis, offering a critical building block for the development of novel active pharmaceutical ingredients (APIs) and functional materials. It is essential for medicinal chemistry researchers and process development scientists in the pharmaceutical, agrochemical, and material science industries who require precise molecular scaffolds for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex heterocyclic compounds for potential therapeutic agents, particularly in oncology and CNS drug discovery.
• Suzuki-Miyaura Cross-Coupling Reactions: The bromo and iodo substituents make it an excellent substrate for palladium-catalyzed cross-coupling to introduce diverse aryl and heteroaryl groups.
• Functional Material Synthesis: Serves as a building block for creating organic electronic materials, such as ligands for OLEDs or charge-transport materials.
• Agrochemical Research: Used in the development of new pesticides and herbicides where the pyrrolopyridine structure confers specific biological activity.
• Chemical Biology Probes: Utilized in the creation of tagged molecular probes for studying biological pathways and target engagement.
• Directed C-H Functionalization: The halogenated structure allows for selective further functionalization via modern metal-catalyzed C-H activation protocols.

Basic Information

Product Name	5-Bromo-3-Iodo-1-Triisopropylsilanyl-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	875639-49-9
Molecular Formula	C16H24BrIN2Si
Molecular Weight	479.27 g/mol
Synonyms	1-[(Triisopropylsilyl)]-5-bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine; 5-Bromo-3-iodo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; TIPS-5-Bromo-3-Iodo-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-3-iodo-1-[(triisopropylsilyl)]-; 875639-49-9; 5-Br-3-I-1-TIPS-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 5-Bromo-3-Iodo-1-Triisopropylsilanyl-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under inert atmosphere when appropriate for prolonged manipulations to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.