Description

1H-Pyrrolo[2,3-b]pyridine, 5-bromo-3-iodo-1-[(4-methylphenyl)sulfonyl]- is a high-purity, multi-halogenated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its precisely functionalized molecular scaffold, which serves as a critical intermediate for constructing complex pharmacophores and functional materials. This compound is primarily needed by research and development teams in the pharmaceutical, agrochemical, and material science industries for drug discovery programs and the development of novel electronic or optoelectronic materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors and other targeted therapeutic agents, particularly in oncology and antiviral research.
• Agrochemical Research: Used to develop novel active ingredients for crop protection by serving as a core heterocyclic structure.
• Material Science: Acts as a building block for organic semiconductors, OLED (Organic Light-Emitting Diode) materials, and other advanced functional materials due to its electron-rich pyrrolopyridine core.
• Chemical Biology: Employed in the design and synthesis of molecular probes and tool compounds for studying biological pathways and target engagement.
• Cross-Coupling Reactions: The bromo and iodo substituents make it an excellent substrate for sequential palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Buchwald-Hartwig) to create diverse compound libraries.
• Academic & Contract Research: Serves as a specialized reagent for methodological development and exploratory synthesis in university and CRO (Contract Research Organization) laboratories.

Basic Information

Product Name	1H-Pyrrolo[2,3-b]pyridine, 5-bromo-3-iodo-1-[(4-methylphenyl)sulfonyl]-
CAS No.	875639-15-9
Molecular Formula	C14H10BrIN2O2S
Molecular Weight	476.11 g/mol
Synonyms	5-Bromo-3-iodo-1-tosyl-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-3-iodo-1-[(4-methylphenyl)sulfonyl]-; 5-Bromo-3-iodo-1-(p-tolylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 5-Bromo-3-iodo-1-(4-methylbenzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1-Tosyl-5-bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine; 5-Br-3-I-1-Ts-7-azaindole; 5-Bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine 1-tosylate
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-3-iodo-1-[(4-methylphenyl)sulfonyl]- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term storage, it is recommended to keep the material at 2-8°C under an inert atmosphere to maintain stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.