Description

6-Chloro-5-Fluoro-2-Iodopyridin-3-Ol is a high-value, multi-halogenated pyridine derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its unique halogen substitution pattern makes it an indispensable building block for constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs). This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of new drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, especially those targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and insecticides, leveraging its halogenated structure for enhanced bioactivity.
• Material Science Research: Serves as a building block for creating novel organic electronic materials, liquid crystals, and advanced polymers.
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl systems.
• Functional Group Transformation: Utilized in medicinal chemistry for further functionalization, enabling the introduction of amines, ethers, and other heterocycles.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development and quality control in chemical manufacturing.

Basic Information

Product Name	6-Chloro-5-Fluoro-2-Iodopyridin-3-Ol
CAS No.	875548-57-5
Molecular Formula	C5H2ClFINO
Molecular Weight	289.43 g/mol
Synonyms	3-Hydroxy-6-chloro-5-fluoro-2-iodopyridine; 6-Chloro-5-fluoro-2-iodopyridin-3-ol; 2-Iodo-6-chloro-5-fluoropyridin-3-ol; 3-Pyridinol, 6-chloro-5-fluoro-2-iodo-; 875548-57-5; 6-Chloro-5-fluoro-2-iodo-3-pyridinol
EINECS	Contact for details

Quality Control

Our 6-Chloro-5-Fluoro-2-Iodopyridin-3-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to supply chain reliability and documentation transparency supports your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.