Description

Anacetrapib is a potent and selective inhibitor of cholesteryl ester transfer protein (CETP) developed for the treatment of dyslipidemia and the prevention of cardiovascular disease. As a high-value pharmaceutical intermediate and reference standard, it is critical for research and development in novel cardiovascular therapies. This compound is essential for pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in metabolic disease research, drug discovery, and analytical method development.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of final drug formulations targeting cholesterol management.
• Reference Standard: Used for quality control, method validation, and calibration in analytical laboratories (HPLC, LC-MS).
• Preclinical & Clinical Research: Serves as an active pharmaceutical ingredient (API) in studies investigating CETP inhibition mechanisms and efficacy.
• Drug Discovery & Development: A vital compound for screening assays and structure-activity relationship (SAR) studies in cardiovascular drug pipelines.
• Academic Research: Utilized in university and institutional labs for fundamental studies on lipid metabolism and atherosclerosis.
• Impurity Standard: Employed to identify and quantify related substances during API and finished product stability testing.

Basic Information

Product Name	Anacetrapib
CAS No.	875446-37-0
Molecular Formula	C₃₀H₂₅F₉N₂O₄
Molecular Weight	637.52 g/mol
Synonyms	MK-0859; Anacetrapibum; (4S,5R)-5-[3,5-Bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)[1,1'-biphenyl]-2-yl]methyl}-4-methyl-1,3-oxazolidin-2-one; CETP Inhibitor MK-0859; 1,3-Oxazolidin-2-one, 5-[3,5-bis(trifluoromethyl)phenyl]-3-[[4'-fluoro-2'-methoxy-5'-(1-methylethyl)-4-(trifluoromethyl)[1,1'-biphenyl]-2-yl]methyl]-4-methyl-, (4S,5R)-
EINECS	Contact for details

Quality Control

Our Anacetrapib is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical research. A Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.