Description

3-[(tert-Butyldimethylsilanyl)Oxy]Azetidine is a specialized organosilicon-protected azetidine derivative, serving as a crucial synthetic intermediate in advanced organic chemistry. Its primary value lies in providing a protected hydroxyl group on the strained azetidine ring, enabling selective reactions in complex multi-step syntheses. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and fine chemicals where the azetidine scaffold is a key structural motif.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates containing the azetidine moiety, a privileged structure in medicinal chemistry.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides that incorporate nitrogen-containing heterocycles for enhanced biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced materials with specific surface properties.
• Peptidomimetics: Integral for constructing conformationally restricted peptide analogs in biochemical research.
• Custom Synthesis & Scale-Up: A critical reagent for contract research organizations (CROs) and CDMOs offering custom synthesis services from milligram to kilogram scale.

Basic Information

Product Name	3-[(tert-Butyldimethylsilanyl)Oxy]Azetidine
CAS No.	875340-81-1
Molecular Formula	C9H21NOSi
Molecular Weight	187.36 g/mol
Synonyms	3-[(tert-Butyldimethylsilyl)oxy]azetidine; 3-(tert-Butyldimethylsiloxy)azetidine; 3-(TBDMSO)azetidine; Azetidin-3-ol, 1-(1,1-dimethylethyl)dimethylsilyl ether; 1-(tert-Butyldimethylsilyloxy)azetidine; TBDMS-protected 3-hydroxyazetidine; 3-Azetidinol, TBDMS ether; 875340-81-1
EINECS	Contact for details

Quality Control

Every batch of 3-[(tert-Butyldimethylsilanyl)Oxy]Azetidine is manufactured and tested under strict quality management systems to ensure consistency and reliability for your critical research and development processes. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.