Description

4-{[3-(Trifluoromethyl)Pyridin-2-Yl]Oxy}Benzenesulfonyl Chloride, 97% is a high-purity, functionalized sulfonyl chloride intermediate of significant importance in advanced organic synthesis. Its core value lies in its dual reactivity, featuring both a sulfonyl chloride group for nucleophilic substitution and a trifluoromethylpyridine ether moiety, making it a versatile building block for creating complex molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly sulfonamides and sulfonate esters. Its specific structure is designed to confer desirable properties such as metabolic stability and enhanced bioavailability to final target compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, especially those targeting enzymes where sulfonamide groups are pharmacologically active.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the trifluoromethyl group often enhances biological activity and environmental stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced functional materials.
• Chemical Biology & Proteomics: Can be utilized as a reactive handle for bioconjugation, labeling proteins, or creating activity-based probes for enzyme studies.
• Custom Synthesis & Contract Manufacturing: A critical intermediate for custom synthesis houses producing bespoke compounds for client R&D programs.
• Library Synthesis for High-Throughput Screening: Enables the rapid generation of diverse compound libraries for drug discovery campaigns.

Basic Information

Item	Details
Product Name	4-{[3-(Trifluoromethyl)Pyridin-2-Yl]Oxy}Benzenesulfonyl Chloride, 97%
CAS No.	874839-13-1
Molecular Formula	C13H9ClF3NO3S
Molecular Weight	351.73 g/mol
Synonyms	4-((3-(Trifluoromethyl)pyridin-2-yl)oxy)benzenesulfonyl chloride; 2-(4-(Chlorosulfonyl)phenoxy)-3-(trifluoromethyl)pyridine; Benzenesulfonyl chloride, 4-[[3-(trifluoromethyl)-2-pyridinyl]oxy]-; 4-((3-(Trifluoromethyl)-2-pyridyl)oxy)benzenesulfonyl chloride; 874839-13-1; 2-Pyridinol, 3-(trifluoromethyl)-, 4-(chlorosulfonyl)phenyl ether
EINECS	Contact for details

Quality Control

Our 4-{[3-(Trifluoromethyl)Pyridin-2-Yl]Oxy}Benzenesulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, to confirm it meets the specified 97% minimum purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. Our quality system is designed to support cGMP-compliant applications for our pharmaceutical sector partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.