Description

(R)-3-Azido-4,4-Dimethyldihydrofuran-2(3H)-One is a high-value chiral building block and key synthetic intermediate. This compound is critical for the stereoselective construction of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs). It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for advanced synthesis and chiral derivatization.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in antiviral, anticancer, and neurological disorder research.
• Agrochemical Synthesis: Used in the development of enantiomerically pure pesticides and herbicides, where specific stereochemistry is crucial for bioactivity.
• Asymmetric Catalysis Research: Serves as a precursor or ligand component in the development of new chiral catalysts and auxiliaries.
• Peptidomimetics & Bioconjugation: The azido group enables efficient "click chemistry" reactions (e.g., CuAAC) for labeling, bioconjugation, and material surface modification.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development and the synthesis of complex natural product analogs.
• Fine Chemical Production: Integral to the multi-step synthesis of specialty chemicals requiring high enantiomeric purity.

Basic Information

Product Name	(R)-3-Azido-4,4-Dimethyldihydrofuran-2(3H)-One
CAS No.	874304-48-0
Molecular Formula	C6H9N3O2
Molecular Weight	155.16 g/mol
Synonyms	(R)-3-Azido-4,4-dimethyl-2-oxotetrahydrofuran; (R)-3-Azido-4,4-dimethylbutyrolactone; (R)-4,4-Dimethyl-3-azidodihydrofuran-2(3H)-one; (3R)-3-Azido-4,4-dimethyloxolan-2-one; (R)-3-Azido-4,4-dimethyl-γ-butyrolactone; Azido-dimethyl-dihydrofuranone (R-enantiomer); (R)-Azido-dimethyl-lactone
EINECS	Contact for details

Quality Control

Our (R)-3-Azido-4,4-Dimethyldihydrofuran-2(3H)-One is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure high chemical and optical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with full characterization data (NMR, IR, MS) are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.