Description

4-Nitrophenyl 2-(Pyridin-2-Yldisulfanyl)Ethyl Carbonate is a specialized heterobifunctional crosslinking reagent featuring a disulfide bond and an activated carbonate group. This compound is engineered for the controlled conjugation of biomolecules, enabling the formation of reversible, cleavable linkages critical for advanced bioconjugation strategies. It is an essential tool for researchers and manufacturers in the fields of pharmaceutical development, proteomics, and diagnostic assay design, where precise and reversible protein modification is required.

Application

• Bioconjugation Reagent: For the site-specific, reversible crosslinking of proteins, peptides, and antibodies via disulfide bond formation.
• Drug-Linker Conjugate Synthesis: A key intermediate in the development of antibody-drug conjugates (ADCs) with cleavable, redox-sensitive linkers.
• Surface Immobilization: Functionalizing sensor chips, nanoparticles, or chromatographic media with ligands that can be released under reducing conditions.
• Proteomics Research: Used in activity-based protein profiling (ABPP) and other chemical proteomics techniques to label and capture enzyme active sites.
• Diagnostic Assay Development: Creating reversible capture systems in immunoassays or biosensors for signal amplification or regeneration.
• Polymer Chemistry: Serving as a functional monomer or crosslinker for synthesizing smart, stimuli-responsive polymers and hydrogels.

Basic Information

Product Name	4-Nitrophenyl 2-(Pyridin-2-Yldisulfanyl)Ethyl Carbonate
CAS No.	874302-76-8
Molecular Formula	C₁₄H₁₂N₂O₅S₂
Molecular Weight	352.39 g/mol
Synonyms	2-(Pyridin-2-yldisulfanyl)ethyl (4-nitrophenyl) carbonate; 4-Nitrophenyl 2-(2-pyridyldithio)ethyl carbonate; PNPDC; 2-(2-Pyridinyldithio)ethyl 4-nitrophenyl carbonate; 4-Nitrophenyl 2-(pyridin-2-yldithio)ethyl carbonate; 2-(Pyridin-2-yldisulfanyl)ethyl 4-nitrophenyl carbonate; 4-Nitrophenyl 2-(2-pyridinyldisulfanyl)ethyl carbonate
EINECS	Contact for details

Quality Control

Our 4-Nitrophenyl 2-(Pyridin-2-Yldisulfanyl)Ethyl Carbonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is light-sensitive (store away from light) and should be handled under inert atmosphere when appropriate to prevent degradation. Keep the container tightly sealed in a desiccated environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.