Description

tert-Butyl 3,4-Dihydro-2H-Spiro[Naphthalene-1,4'-Piperidine]-1'-Carboxylate CAS NO 873779-29-4 is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and piperidine scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for synthesizing novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical companies engaged in the discovery and development of new therapeutic agents, particularly within central nervous system (CNS) and oncology drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of complex drug candidates and novel chemical entities.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Employed in the development and scale-up of Active Pharmaceutical Ingredients (APIs), particularly those targeting neurological receptors.
• Chemical Biology Probes: Serves as a core structure for developing molecular probes to study biological pathways and protein functions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis services catering to the pharmaceutical and biotechnology industries.

Basic Information

Product Name	tert-Butyl 3,4-Dihydro-2H-Spiro[Naphthalene-1,4'-Piperidine]-1'-Carboxylate
CAS No.	873779-29-4
Molecular Formula	C19H25NO2
Molecular Weight	299.41 g/mol
Synonyms	1'-Boc-1,2,3,4-tetrahydrospiro[naphthalene-1,4'-piperidine]; tert-Butyl 1,2,3,4-tetrahydrospiro[naphthalene-1,4'-piperidine]-1'-carboxylate; 1,2,3,4-Tetrahydrospiro[naphthalene-1,4'-piperidine]-1'-carboxylic acid tert-butyl ester; 1,2,3,4-Tetrahydro-1,4'-spiro[naphthalene-1,4'-piperidine]-1'-carboxylic acid tert-butyl ester; 873779-29-4; Spiro[naphthalene-1,4'-piperidine]-1'-carboxylic acid, 3,4-dihydro-2H-, 1,1-dimethylethyl ester; Boc-protected spirocyclic piperidine naphthalene derivative
EINECS	Contact for details

Quality Control

Our tert-Butyl 3,4-Dihydro-2H-Spiro[Naphthalene-1,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with the standards required for pharmaceutical R&D and cGMP starting material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed and under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.