Description

Spiro[2.3]Hexane-5-Carbonitrile is a specialized spirocyclic nitrile building block of significant interest in advanced organic synthesis. This compound matters for its unique three-dimensional structure, which provides a rigid, sterically defined scaffold for constructing complex molecular architectures. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Used in the research and development of new herbicides and pesticides, where its spirocyclic core can contribute to unique biological activity.
• Ligand and Catalyst Development: Employed as a building block for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Acts as a monomer or cross-linking agent in the development of specialty polymers with tailored thermal or mechanical properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry, exploring new cyclization and functionalization reactions.

Basic Information

Product Name	Spiro[2.3]Hexane-5-Carbonitrile
CAS No.	872988-59-5
Molecular Formula	C8H9N
Molecular Weight	119.16 g/mol
Synonyms	Spiro[2.3]hexane-5-carbonitrile; 5-Cyanospiro[2.3]hexane; 1-Azaspiro[2.3]hexane-1-carbonitrile (tautomeric form); Spirohexane-5-carbonitrile; 5-Spirohexanecarbonitrile; 872988-59-5; SCHEMBL23846899; AKOS040759977
EINECS	Contact for details

Quality Control

Our Spiro[2.3]Hexane-5-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 95.0% (Research Grade)
Purity (HPLC/GC)	≥ 98.0% (Premium Grade)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.