Description

5-Isocyano-1-Methyl-1H-Indole is a versatile and highly reactive heterocyclic building block, primarily valued for its isocyano functional group which serves as a key precursor in metal-catalyzed coupling and cycloaddition reactions. This compound is essential for the efficient synthesis of complex nitrogen-containing heterocycles, including indole-based pharmaceuticals and advanced materials. It is particularly sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel molecular scaffolds.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel indole-based drug candidates, particularly for oncology and central nervous system (CNS) targets.
• Agrochemical Synthesis: Used in the development of new pesticides and herbicides, leveraging its reactivity to create complex bioactive molecules.
• Material Science: Serves as a building block for functional polymers, dyes, and organic electronic materials due to its conjugated indole core.
• Catalysis & Ligand Development: The isocyano group acts as a versatile ligand for transition metals, useful in designing novel catalytic systems.
• Academic & Contract Research: Employed in research laboratories for methodological development in organic synthesis and heterocyclic chemistry.
• Combinatorial Chemistry: A valuable scaffold for generating diverse chemical libraries in high-throughput screening for drug discovery.

Basic Information

Product Name	5-Isocyano-1-Methyl-1H-Indole
CAS No.	872526-29-9
Molecular Formula	C10H8N2
Molecular Weight	156.19 g/mol
Synonyms	1-Methyl-5-isocyanoindole; 1-Methyl-1H-indole-5-carbonitrile; 5-Isocyano-1-methylindole; 1-Methylindole-5-carbonitrile; 5-Cyano-1-methyl-1H-indole; 872526-29-9; 1H-Indole-5-carbonitrile, 1-methyl-
EINECS	Contact for details

Quality Control

Our 5-Isocyano-1-Methyl-1H-Indole is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of research and development as well as scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended long-term storage temperature is 2-8°C. Allow the container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.