Description

(Benzofuran-5-Yloxy)(tert-Butyl)Dimethylsilane is a specialized organosilicon protecting group reagent, primarily used for the selective protection of hydroxyl groups in complex organic synthesis. Its value lies in its ability to introduce the robust tert-butyldimethylsilyl (TBDMS) ether protecting group onto benzofuran scaffolds, a critical step in multi-step synthetic pathways. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require high-purity intermediates for the development of active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for protecting hydroxyl groups on benzofuran-containing drug candidates during multi-step synthesis.
• Agrochemical Development: Used in the research and production of novel herbicides, fungicides, and insecticides that incorporate benzofuran motifs.
• Organic Light-Emitting Diode (OLED) Materials: Serves as a precursor in the synthesis of advanced organic semiconductors and emissive layer materials.
• Academic & Contract Research: A valuable reagent for methodology development and complex natural product synthesis in university and CRO laboratories.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances requiring selective protection/deprotection strategies.

Basic Information

Product Name	(Benzofuran-5-Yloxy)(tert-Butyl)Dimethylsilane
CAS No.	872413-47-3
Molecular Formula	C₁₄H₂₀O₂Si
Molecular Weight	248.40 g/mol
Synonyms	5-[(tert-Butyldimethylsilyl)oxy]benzofuran; Benzofuran-5-ol, TBDMS ether; 5-(tert-Butyldimethylsiloxy)benzofuran; 5-TBDMS-O-Benzofuran; tert-Butyl((benzofuran-5-yl)oxy)dimethylsilane; 5-Hydroxybenzofuran tert-butyldimethylsilyl ether; TBDMS Benzofuran-5-yl Ether
EINECS	Contact for details

Quality Control

Every batch of (Benzofuran-5-Yloxy)(tert-Butyl)Dimethylsilane is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and commercial synthesis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, NMR, and IR is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.