Description

2-Bromo-6-(Difluoromethyl)Pyridine is a versatile halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and difluoromethyl substituents, makes it a valuable precursor for introducing fluorinated motifs into complex molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and CNS-active compounds.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the difluoromethyl group can improve metabolic stability and bioavailability.
• Material Science Precursor: Employed in the synthesis of specialty chemicals, liquid crystals, and functionalized ligands for catalytic systems.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl systems.
• Fluorine Chemistry Research: Serves as a standard reagent in academic and industrial labs studying the effects of fluorination on molecular properties.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring specific fluorinated pyridine scaffolds.

Basic Information

Product Name	2-Bromo-6-(Difluoromethyl)Pyridine
CAS No.	872365-91-8
Molecular Formula	C6H4BrF2N
Molecular Weight	207.99 g/mol
Synonyms	6-(Difluoromethyl)-2-bromopyridine; 2-Bromo-6-difluoromethylpyridine; Pyridine, 2-bromo-6-(difluoromethyl)-; 872365-91-8; 2-Bromo-6-(difluoromethyl)pyridin; 2-Br-6-(CHF2)Py
EINECS	Contact for details

Quality Control

Our 2-Bromo-6-(Difluoromethyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque or amber glass, or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.