Description

Imidazo[1,2-A]Pyridine, 2-(Chloromethyl)-6-Fluoro- CAS NO 872363-18-3 is a high-value, multi-functional heterocyclic building block characterized by its fused imidazole and pyridine rings with reactive chloromethyl and fluoro substituents. This compound is critical for medicinal chemistry research and the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs. It serves as a key synthetic intermediate for pharmaceutical, agrochemical, and advanced material scientists seeking to incorporate its unique pharmacophore into target molecules.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of kinase inhibitors, antiviral agents, and other small molecule therapeutics.
• Agrochemical Research: Used in the development of novel fungicides and herbicides due to its bioactive heterocyclic core.
• Material Science: Serves as a building block for creating functionalized organic ligands and advanced polymers.
• Chemical Synthesis: Utilized in cross-coupling reactions and as a scaffold for constructing complex nitrogen-containing heterocycles.
• Bioconjugation: The reactive chloromethyl group enables its use in linker chemistry for antibody-drug conjugates (ADCs) and probe molecules.
• Academic & R&D: A valuable reagent for exploring new synthetic methodologies and structure-activity relationships (SAR) in academic and industrial laboratories.

Basic Information

Product Name	Imidazo[1,2-A]Pyridine, 2-(Chloromethyl)-6-Fluoro-
CAS No.	872363-18-3
Molecular Formula	C8H6ClFN2
Molecular Weight	184.60 g/mol
Synonyms	2-(Chloromethyl)-6-fluoroimidazo[1,2-a]pyridine; 6-Fluoro-2-(chloromethyl)imidazo[1,2-a]pyridine; 2-Chloromethyl-6-fluoroimidazo[1,2-a]pyridine; Imidazo[1,2-a]pyridine, 2-(chloromethyl)-6-fluoro-; 872363-18-3; 6-Fluoroimidazo[1,2-a]pyridine-2-methanol, 2-chloro derivative
EINECS	Contact for details

Quality Control

Our Imidazo[1,2-A]Pyridine, 2-(Chloromethyl)-6-Fluoro- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent chemical identity. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.