Description

7'-Fluoro-Spiro[Cyclopropane-1,3'-[3H]Indol]-2'(1'H)-One is a high-value, fluorinated spirocyclic indolinone compound, serving as a sophisticated building block in advanced organic synthesis. Its unique molecular architecture, featuring a fused cyclopropane and indolone ring system, is critical for modulating biological activity and physicochemical properties in target molecules. This intermediate is essential for research and development chemists in the pharmaceutical and agrochemical sectors, where it is used to create novel active ingredients with enhanced potency and selectivity.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the design and synthesis of novel pesticides and herbicides, leveraging the fluorine atom for improved metabolic stability and bioavailability.
• Chemical Biology Probe Development: Employed as a core scaffold for creating molecular probes to study enzyme function and protein-protein interactions.
• Material Science Research: Investigated as a precursor for specialty polymers and advanced organic materials with specific electronic or photophysical properties.
• Medicinal Chemistry SAR Studies: Utilized to explore structure-activity relationships (SAR) by introducing the spirocyclic and fluoro motifs into lead compounds.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations for custom synthesis and process development projects.

Basic Information

Product Name	7'-Fluoro-Spiro[Cyclopropane-1,3'-[3H]Indol]-2'(1'H)-One
CAS No.	872141-30-5
Molecular Formula	C10H8FNO
Molecular Weight	177.18 g/mol
Synonyms	7'-Fluorospiro[cyclopropane-1,3'-indol]-2'(1'H)-one; 2'H-Spiro[cyclopropane-1,3'-indol]-2'-one, 7'-fluoro-; 7'-Fluoro-1'H-spiro[cyclopropane-1,3'-indol]-2'-one; 7-Fluoro-spiro[cyclopropane-1,3-indolin]-2-one; Spiro[cyclopropane-1,3'-indole]-2'(1'H)-one, 7'-fluoro-; 872141-30-5; FC Spiro Indolinone
EINECS	Contact for details

Quality Control

Our 7'-Fluoro-Spiro[Cyclopropane-1,3'-[3H]Indol]-2'(1'H)-One is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.