Description

Dimethyl 2-(3-Fluoro-2-Nitrophenyl)Malonate is a high-purity fluorinated aromatic building block, specifically a substituted malonate ester, essential for advanced organic synthesis. Its molecular structure, featuring both a nitro and a fluoro substituent on the phenyl ring, makes it a versatile intermediate for constructing complex molecules with precise electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of fluorinated drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the fluorine atom enhances bioavailability and metabolic stability.
• Material Science Research: Serves as a precursor for functionalized monomers in the creation of specialty polymers and advanced organic electronic materials.
• Chemical Biology Probes: Employed in the design and synthesis of fluorinated molecular probes and tags for studying biological mechanisms.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions, such as Suzuki or Buchwald-Hartwig amination, to form complex biaryl structures.
• Nucleophilic Aromatic Substitution: The nitro and fluoro groups make it an excellent substrate for nucleophilic aromatic substitution (SNAr) reactions, enabling diverse functionalization.

Basic Information

Product Name	Dimethyl 2-(3-Fluoro-2-Nitrophenyl)Malonate
CAS No.	872141-24-7
Molecular Formula	C12H12FNO6
Molecular Weight	285.23 g/mol
Synonyms	Dimethyl (3-Fluoro-2-nitrobenzyl)malonate; Propanedioic acid, 2-(3-fluoro-2-nitrophenyl)-, 1,3-dimethyl ester; 2-(3-Fluoro-2-nitrophenyl)malonic Acid Dimethyl Ester; Malonic acid, (3-fluoro-2-nitrophenyl)-, dimethyl ester; Dimethyl 2-(3-fluoro-2-nitrophenyl)propanedioate
EINECS	Contact for details

Quality Control

Our Dimethyl 2-(3-Fluoro-2-Nitrophenyl)Malonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.