Description

Acetic Acid (2R,3S)-3-Dibenzylamino-2-Hydroxy-4-Phenylbutyl Ester is a high-purity, chiral synthetic intermediate of significant importance in advanced pharmaceutical research and development. This compound is specifically engineered for applications requiring precise stereochemistry, serving as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily needed by R&D laboratories, process chemists, and manufacturers in the pharmaceutical and fine chemical industries focused on developing novel therapeutics, particularly in the areas of protease inhibitors and other targeted drug molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially protease inhibitors.
• Peptidomimetic Research: Used in the design and construction of peptide-like molecules for drug discovery programs.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to introduce specific stereocenters.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Process Development: Used in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing.
• Reference Standard: Can be utilized as an analytical standard for quality control and method development in API production.

Basic Information

Product Name	Acetic Acid (2R,3S)-3-Dibenzylamino-2-Hydroxy-4-Phenylbutyl Ester
CAS No.	871948-95-7
Molecular Formula	C26H29NO3
Molecular Weight	403.52 g/mol
Synonyms	(2R,3S)-3-(Dibenzylamino)-2-hydroxy-4-phenylbutyl acetate; 1-[(2R,3S)-3-(Dibenzylamino)-2-hydroxy-4-phenylbutyl] acetate; N,N-Dibenzyl-3-phenylisoserine acetate ester; (2R,3S)-Epoxybenzylamine derivative acetate; Chiral β-amino alcohol acetate ester; A chiral phenylbutylamine acetate; DBU-Phe acetate derivative (informal); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Acetic Acid (2R,3S)-3-Dibenzylamino-2-Hydroxy-4-Phenylbutyl Ester is produced under strict quality management systems suitable for research and pharmaceutical development. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure high chemical and stereochemical purity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with internal quality standards and regulatory documentation requirements for pre-clinical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); ensure the container is sealed after each use to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.