Description

Piperidine, 3-Fluoro-, Hydrochloride (1:1), (3S)- is a high-purity, single-enantiomer chiral building block of significant importance in advanced organic synthesis. This compound is a key intermediate for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals, where its defined stereochemistry and fluorine substituent are critical for modulating biological activity and physicochemical properties. It is primarily required by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries engaged in the development of fluorinated, nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and synthesis of potential drug candidates, particularly in central nervous system (CNS) and metabolic disorder therapeutic areas.
• Agrochemical Research: Used in the development of new-generation fluorinated pesticides and herbicides, where the fluorine atom enhances stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex fluorinated piperidine derivatives for various high-value specialty chemicals.
• Academic & R&D: A valuable reagent for methodological studies in organic chemistry, focusing on fluorination chemistry and stereoselective transformations.

Basic Information

Product Name	Piperidine, 3-Fluoro-, Hydrochloride (1:1), (3S)-
CAS No.	871664-50-5
Molecular Formula	C5H11ClFN
Molecular Weight	139.60 g/mol
Synonyms	(3S)-3-Fluoropiperidine hydrochloride; (S)-3-Fluoropiperidine hydrochloride; (-)-3-Fluoropiperidine hydrochloride; 3-Fluoropiperidine hydrochloride, (S)-; 3-Fluoro-(S)-piperidine hydrochloride; (S)-3-Fluoropiperidinium chloride; 3-Fluoropiperidine HCl, (S)-enantiomer; L-3-Fluoropiperidine hydrochloride
EINECS	Contact for details

Quality Control

Our Piperidine, 3-Fluoro-, Hydrochloride (1:1), (3S)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and advanced synthesis. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (assay), enantiomeric excess, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.