Description

5-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]hexahydro-4-(hydroxymethyl)-(3As,4S,5R,6Ar)-2(1H)-pentalenone is a high-value, stereochemically defined synthetic intermediate featuring a protected hydroxyl group. This compound is critical for enabling complex, multi-step organic syntheses where precise control over molecular architecture and functional group manipulation is required. It is primarily sought by research and development teams in the pharmaceutical and fine chemical industries for the synthesis of novel active pharmaceutical ingredients (APIs) and other advanced organic molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex, chiral drug candidates and active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Utilized as a chiral synthon in stereoselective reactions to construct molecules with defined three-dimensional structures.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, agrochemicals, and advanced materials requiring high-purity intermediates.
• Process Chemistry Development: Used in route scouting and scale-up studies for the efficient production of target molecules.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic synthesis and catalysis research.

Basic Information

Item	Details
Product Name	5-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]hexahydro-4-(hydroxymethyl)-(3As,4S,5R,6Ar)-2(1H)-pentalenone
CAS No.	871095-04-4
Molecular Formula	C16H30O3Si
Molecular Weight	298.50 g/mol
Synonyms	(3aS,4S,5R,6aR)-4-(Hydroxymethyl)hexahydro-5-[(tert-butyldimethylsilyl)oxy]-2(1H)-pentalenone; 5-[(tert-Butyldimethylsilyl)oxy]hexahydro-4-(hydroxymethyl)-(3aS,4S,5R,6aR)-2(1H)-pentalenone; TBS-protected pentalenone derivative; tert-Butyldimethylsilyl ether of a hydroxymethyl pentalenone; Chiral TBS-pentalenone intermediate; CAS 871095-04-4
EINECS	Contact for details

Quality Control

Every batch of our 5-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]hexahydro-4-(hydroxymethyl)-(3As,4S,5R,6Ar)-2(1H)-pentalenone undergoes rigorous analytical testing to ensure identity, purity, and stereochemical integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, enantiomeric excess, and impurity profiles. Our quality management system is designed to support cGMP compliance for pharmaceutical applications, ensuring traceability and reliability for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.