Description

tert-Butyl-4-fluoroisoindoline-2-carboxylate is a high-purity fluorinated isoindoline derivative, serving as a critical protected intermediate in advanced organic synthesis. Its value lies in enabling the efficient construction of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality building blocks for drug discovery and process optimization.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that incorporate fluorinated heterocyclic structures for enhanced efficacy.
• Fine Chemical Production: Serves as a versatile precursor for creating complex fluorinated organic molecules used in material science and specialty chemistry.
• Protecting Group Strategy: The tert-butyloxycarbonyl (Boc) group provides a stable, orthogonal protecting group for secondary amines, facilitating multi-step synthetic sequences.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies by providing a scaffold for introducing fluorine atoms, which can improve metabolic stability and binding affinity.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for commercial manufacturing of target molecules.

Basic Information

Item	Detail
Product Name	tert-Butyl-4-fluoroisoindoline-2-carboxylate
CAS No.	871013-93-3
Molecular Formula	C₁₃H₁₆FNO₂
Molecular Weight	237.27 g/mol
Synonyms	4-Fluoro-2,3-dihydro-1H-isoindole-2-carboxylic acid tert-butyl ester; 1,3-Dihydro-4-fluoro-2H-isoindole-2-carboxylic acid 1,1-dimethylethyl ester; Boc-4-fluoroisoindoline; tert-Butyl 4-fluoro-2,3-dihydro-1H-isoindole-2-carboxylate; 4-Fluoro-isoindoline-2-carboxylic acid tert-butyl ester; 2-(tert-Butoxycarbonyl)-4-fluoroisoindoline; 871013-93-3
EINECS	Contact for details

Quality Control

Our tert-Butyl-4-fluoroisoindoline-2-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with the standards expected for pharmaceutical intermediates, supporting our customers' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in a dark place.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.