Description

3-(tert-Butoxycarbonylamino)-2-Methoxyisonicotinic Acid is a high-purity, protected amino acid derivative and a key pharmaceutical intermediate. Its value lies in its role as a versatile building block for the synthesis of complex molecules, particularly in medicinal chemistry. This compound is essential for research and development chemists in the pharmaceutical and biotechnology industries, where it is used to construct novel active pharmaceutical ingredients (APIs) and other fine chemicals. The product is supplied with a CAS registry number of 870997-82-3.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Peptidomimetics Synthesis: Used to incorporate modified amino acid structures into peptide analogs to enhance stability, bioavailability, and biological activity.
• Protecting Group Chemistry: The tert-butoxycarbonyl (Boc) group protects the amine functionality during complex synthetic sequences, allowing for selective deprotection later.
• Medicinal Chemistry Research: Serves as a scaffold for structure-activity relationship (SAR) studies and the discovery of new bioactive compounds in academic and industrial R&D labs.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.
• Chemical Biology Probes: Can be utilized to create labeled or tagged molecules for studying biological pathways and target engagement.

Basic Information

Product Name	3-(tert-Butoxycarbonylamino)-2-Methoxyisonicotinic Acid
CAS No.	870997-82-3
Molecular Formula	C12H16N2O5
Molecular Weight	268.27 g/mol
Synonyms	2-Methoxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]pyridine-4-carboxylic acid; 3-[(tert-Butoxycarbonyl)amino]-2-methoxy-4-pyridinecarboxylic acid; 3-(Boc-amino)-2-methoxyisonicotinic acid; 3-(tert-Butoxycarbonylamino)-2-methoxypyridine-4-carboxylic acid; Boc-3-amino-2-methoxyisonicotinic acid; 4-Pyridinecarboxylic acid, 3-[(1,1-dimethylethoxy)carbonyl]amino-2-methoxy-; 870997-82-3
EINECS	Contact for details

Quality Control

Our 3-(tert-Butoxycarbonylamino)-2-Methoxyisonicotinic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP compliance for advanced intermediates, and we can accommodate specific customer requirements for analytical methods and specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.