Description

4-Chloro-7-[Tris(1-methylethyl)silyl]-7H-pyrrolo[2,3-d]pyrimidine CAS NO 870706-50-6 is a high-value, organosilicon-protected heterocyclic building block. This compound is critical for synthetic chemists as it provides a versatile and reactive scaffold for constructing complex molecules, particularly in nucleoside and pharmaceutical chemistry. It is primarily needed by R&D and process development teams in the pharmaceutical, agrochemical, and advanced material sectors for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside analogs and kinase inhibitors for therapeutic development.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides that require specific heterocyclic frameworks.
• Organic Light-Emitting Diode (OLED) Materials: Serves as a building block for electron-transport or host materials in display and lighting technologies.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies and the discovery of new chemical entities.
• Protecting Group Strategy: The trisopropylsilyl (TIPS) group offers steric protection for the pyrrolopyrimidine nitrogen, enabling selective functionalization at other sites on the molecule.
• Cross-Coupling Reactions: The chloro substituent at the 4-position makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination.

Basic Information

Product Name	4-Chloro-7-[Tris(1-methylethyl)silyl]-7H-pyrrolo[2,3-d]pyrimidine
CAS No.	870706-50-6
Molecular Formula	C15H24ClN3Si
Molecular Weight	309.91 g/mol
Synonyms	4-Chloro-7-(triisopropylsilyl)-7H-pyrrolo[2,3-d]pyrimidine; 4-Chloro-7-triisopropylsilyl-7H-pyrrolo[2,3-d]pyrimidine; 7H-Pyrrolo[2,3-d]pyrimidine, 4-chloro-7-[tris(1-methylethyl)silyl]-; 4-Chloro-7-TIPS-7H-pyrrolo[2,3-d]pyrimidine; TIPS-protected 4-chloropyrrolopyrimidine; 870706-50-6; 4-Chloro-7-(triisopropylsilyl)pyrrolo[2,3-d]pyrimidine
EINECS	Contact for details

Quality Control

Our production of 4-Chloro-7-[Tris(1-methylethyl)silyl]-7H-pyrrolo[2,3-d]pyrimidine adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and MS are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.