Description

2-Chloro-3-Fluoro-4-Cyanopyridine is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its unique halogenated and nitrile-substituted pyridine core makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine and chlorine atoms can enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a building block for functionalized polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing cyano group.
• Chemical Research & Development: Employed in academic and industrial R&D labs for method development, cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig), and as a scaffold for library synthesis in drug discovery.
• Ligand and Catalyst Design: The pyridine nitrogen and substituents make it a candidate for designing novel chelating ligands and organocatalysts.

Basic Information

Product Name	2-Chloro-3-Fluoro-4-Cyanopyridine
CAS No.	870065-56-8
Molecular Formula	C6H2ClFN2
Molecular Weight	156.55 g/mol
Synonyms	4-Cyano-2-chloro-3-fluoropyridine; 3-Fluoro-2-chloro-4-cyanopyridine; 2-Chloro-3-fluoro-4-pyridinecarbonitrile; 870065-56-8; 2-Chloro-3-fluoropyridine-4-carbonitrile; 4-Pyridinecarbonitrile, 2-chloro-3-fluoro-
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-3-Fluoro-4-Cyanopyridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high standards required for research and commercial synthesis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.