Description

(2-Bromopyridin-3-Yl)Methanamine Dihydrochloride is a high-purity, versatile brominated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in enabling the construction of complex molecular architectures, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process R&D teams in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for drug discovery programs and the synthesis of active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Scaffold: Used extensively in hit-to-lead and lead optimization campaigns to introduce the 2-bromo-3-aminomethylpyridine moiety, enabling further functionalization via cross-coupling reactions.
• Agrochemical Synthesis: Serves as a building block for developing novel herbicides, fungicides, and insecticides that incorporate halogenated pyridine structures.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for metal-catalyzed reactions and organocatalysts due to its coordinating nitrogen atoms.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems and target engagement.
• Material Science Research: Acts as a monomer or functionalizing agent in the development of advanced polymers and organic electronic materials.

Basic Information

Product Name	(2-Bromopyridin-3-Yl)Methanamine Dihydrochloride
CAS No.	870064-21-4
Molecular Formula	C6H8BrCl2N2
Molecular Weight	256.95 g/mol
Synonyms	1-(2-Bromopyridin-3-yl)methanamine dihydrochloride; 2-Bromo-3-(aminomethyl)pyridine dihydrochloride; (2-Bromo-3-pyridinyl)methanamine dihydrochloride; 3-(Aminomethyl)-2-bromopyridine dihydrochloride; 2-Bromo-3-pyridinemethanamine dihydrochloride; 2-Bromonicotinylamine dihydrochloride; 2-Bromo-3-pyridylmethylamine dihydrochloride
EINECS	Contact for details

Quality Control

Our (2-Bromopyridin-3-Yl)Methanamine Dihydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and scale-up. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.