Description

4,6-Bis-Difluoromethyl-2-Hydroxy-Nicotinonitrile is a specialized pyridine derivative featuring difluoromethyl and nitrile functional groups. This compound is a critical high-purity intermediate valued for its unique reactivity and fluorine content, which imparts desirable properties to final products. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for creating fluorinated organic materials, such as liquid crystals, polymers, and electronic chemicals.
• Chemical Biology Probes: Employed in the design and synthesis of fluorinated probes and tags for studying biological mechanisms and drug-target interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP conditions.

Basic Information

Product Name	4,6-Bis-Difluoromethyl-2-Hydroxy-Nicotinonitrile
CAS No.	869945-81-3
Molecular Formula	C9H5F4N2O
Molecular Weight	224.14 g/mol
Synonyms	2-Hydroxy-4,6-bis(difluoromethyl)nicotinonitrile; 4,6-Bis(difluoromethyl)-2-hydroxynicotinonitrile; 2-Hydroxy-4,6-bis(difluoromethyl)-3-cyanopyridine; 3-Cyano-2-hydroxy-4,6-bis(difluoromethyl)pyridine; 869945-81-3; Nicotinonitrile, 4,6-bis(difluoromethyl)-2-hydroxy-
EINECS	Contact for details

Quality Control

Every batch of 4,6-Bis-Difluoromethyl-2-Hydroxy-Nicotinonitrile is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure lot-to-lot consistency and compliance with your project specifications. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting purity, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.