Description

4-Cyclopropyl-6-Difluoromethyl-2-Hydroxy-Nicotinonitrile is a high-value, multi-functional heterocyclic building block designed for advanced chemical synthesis. Its unique molecular structure, featuring a cyclopropyl ring and a difluoromethyl group, makes it a critical intermediate for developing novel active ingredients with enhanced properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of new drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Serves as a versatile precursor in the design and synthesis of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the pyridine and difluoromethyl motifs.
• Chemical Research: Used in academic and industrial R&D labs for exploring novel heterocyclic chemistry, fluorination effects, and structure-activity relationships (SAR).
• Material Science Precursor: Potential application as a building block for specialty chemicals, ligands, or functional materials requiring specific electronic properties.

Basic Information

Product Name	4-Cyclopropyl-6-Difluoromethyl-2-Hydroxy-Nicotinonitrile
CAS No.	869944-65-0
Molecular Formula	C10H8F2N2O
Molecular Weight	210.18 g/mol
Synonyms	2-Hydroxy-4-cyclopropyl-6-(difluoromethyl)nicotinonitrile; 4-Cyclopropyl-6-(difluoromethyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile; 6-(Difluoromethyl)-4-cyclopropyl-2-hydroxynicotinonitrile; 2-Hydroxy-4-cyclopropyl-6-difluoromethylnicotinonitrile; 3-Cyano-4-cyclopropyl-6-(difluoromethyl)-2-pyridinol; 4-Cyclopropyl-6-difluoromethyl-2-hydroxypyridine-3-carbonitrile
EINECS	Contact for details

Quality Control

Our 4-Cyclopropyl-6-Difluoromethyl-2-Hydroxy-Nicotinonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.