Description

6-(Difluoromethyl)-2-Hydroxy-4-Methylnicotinonitrile (Saltdata: Free) is a high-value, functionalized pyridine derivative that serves as a critical synthetic intermediate. Its molecular structure, featuring a difluoromethyl group and a nitrile moiety, makes it a versatile building block for constructing complex molecules with tailored properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting new therapeutic agents.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance metabolic stability and bioavailability.
• Material Science Precursor: Serves as a starting material for creating specialized ligands, functional polymers, or liquid crystal compounds.
• Chemical Biology Probe: Utilized in medicinal chemistry to explore structure-activity relationships (SAR) and develop chemical probes for biological targets.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific fluorinated heterocycles.

Basic Information

Product Name	6-(Difluoromethyl)-2-Hydroxy-4-Methylnicotinonitrile (Saltdata: Free)
CAS No.	869942-32-5
Molecular Formula	C8H6F2N2O
Molecular Weight	184.15 g/mol
Synonyms	2-Hydroxy-6-(difluoromethyl)-4-methylnicotinonitrile; 4-Methyl-6-(difluoromethyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile; 6-(Difluoromethyl)-2-hydroxy-4-methyl-3-cyanopyridine; 2-Hydroxy-4-methyl-6-(difluoromethyl)nicotinonitrile; 3-Cyano-6-(difluoromethyl)-4-methyl-2(1H)-pyridinone
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for all our fine chemical intermediates. Each batch of 6-(Difluoromethyl)-2-Hydroxy-4-Methylnicotinonitrile is analyzed using advanced techniques like HPLC, NMR, and GC-MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, and we support custom purity requirements for research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.