Description

5-Nitro-3-((trimethylsilyl)ethynyl)pyridin-2-amine is a high-purity, advanced pharmaceutical intermediate featuring a unique pyridine core functionalized with nitro and silyl-protected ethynyl groups. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules for drug discovery and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate sophisticated heterocyclic scaffolds into their target compounds.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in developing new crop protection agents and herbicides due to its reactive nitro and alkyne functionalities.
• Material Science: Acts as a monomer or cross-linking agent in the development of advanced polymers and functional materials.
• Chemical Biology Probes: Utilized in creating labeled compounds and probes for studying biological pathways and target engagement.
• Organic Synthesis Building Block: Employed in Sonogashira and other cross-coupling reactions to construct complex molecular architectures.

Basic Information

Product Name	5-Nitro-3-((Trimethylsilyl)Ethynyl)Pyridin-2-Amine
CAS No.	869884-26-4
Molecular Formula	C10H15N3O2Si
Molecular Weight	237.34 g/mol
Synonyms	2-Amino-5-nitro-3-[(trimethylsilyl)ethynyl]pyridine; 3-Ethynyl-5-nitro-2-pyridinamine, 3-(trimethylsilyl)-; 5-Nitro-3-(2-trimethylsilylethynyl)pyridin-2-ylamine; 2-Pyridinamine, 3-[(trimethylsilyl)ethynyl]-5-nitro-; 869884-26-4; 5-Nitro-3-(trimethylsilylethynyl)pyridin-2-amine
EINECS	Contact for details

Quality Control

Our 5-Nitro-3-((trimethylsilyl)ethynyl)pyridin-2-amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Keep away from heat, sparks, and open flame. Due to its light-sensitive and easily oxidized nature, prolonged exposure to air and light should be avoided.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.