Description

(2-Iodo-Pyridin-4-Yl)-Carbamic Acid tert-Butyl Ester is a high-value, iodinated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its core value lies in providing a protected amine and a versatile halogen handle for cross-coupling reactions, enabling the efficient construction of complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its reactive iodine for structural diversification.
• Material Science Research: Employed in the creation of functionalized ligands for catalysis and novel organic electronic materials.
• Cross-Coupling Reactions: Serves as a superior substrate for Suzuki-Miyaura, Stille, and other palladium-catalyzed cross-coupling reactions due to the activated iodine on the pyridine ring.
• Chemical Biology & Proteomics: Utilized as a building block for synthesizing molecular probes and affinity tags for studying biological systems.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	(2-Iodo-Pyridin-4-Yl)-Carbamic Acid tert-Butyl Ester
CAS No.	869735-25-1
Molecular Formula	C10H13IN2O2
Molecular Weight	320.13 g/mol
Synonyms	tert-Butyl N-(2-iodopyridin-4-yl)carbamate; N-Boc-2-iodopyridin-4-amine; 2-Iodo-4-((tert-butoxycarbonyl)amino)pyridine; 4-((tert-Butoxycarbonyl)amino)-2-iodopyridine; Boc-2-I-4-APy; 869735-25-1; (2-Iodo-4-pyridinyl)carbamic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Every batch of (2-Iodo-Pyridin-4-Yl)-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency meet the exacting standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.