Description

n-Methyl 2-Bromo-5-Pyridinecarboxamide is a high-purity, specialized brominated pyridine derivative serving as a critical building block in advanced organic synthesis. Its value lies in providing a reactive halogen site and a protected amide functional group, enabling precise molecular construction for complex targets. This intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Building block for developing new herbicides, fungicides, and insecticides with targeted modes of action.
• Ligand Synthesis: Used in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Material Science: Intermediate for creating functionalized polymers and advanced organic electronic materials.
• Cross-Coupling Reactions: Serves as a substrate in Suzuki, Stille, and Buchwald-Hartwig amination reactions due to the reactive bromine atom.
• Chemical Biology: Useful for synthesizing molecular probes and labeled compounds for biochemical studies.

Basic Information

Product Name	n-Methyl 2-Bromo-5-Pyridinecarboxamide
CAS No.	869640-48-2
Molecular Formula	C8H7BrN2O
Molecular Weight	227.06 g/mol
Synonyms	2-Bromo-5-[(methylamino)carbonyl]pyridine; 2-Bromo-N-methylnicotinamide; 2-Bromo-5-pyridinecarboxylic acid methylamide; N-Methyl-2-bromonicotinamide; 2-Bromo-5-carbamoylpyridine, N-methyl; Methyl (2-bromo-5-pyridyl)carbamate (incorrect but common); 869640-48-2; 2-Bromo-5-(N-methylcarbamoyl)pyridine
EINECS	Contact for details

Quality Control

Our n-Methyl 2-Bromo-5-Pyridinecarboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.