Description

Pyrrolidine, 3,4-Difluoro-, Hydrochloride (1:1), (3S,4R)-Rel- is a high-purity, stereochemically defined fluorinated pyrrolidine derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in the precise introduction of fluorine atoms and a defined three-dimensional structure, which are essential for modulating the biological activity, metabolic stability, and physicochemical properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the discovery and process development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides where the fluorinated pyrrolidine core can enhance activity and environmental profile.
• Ligand & Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probe Synthesis: Employed to build molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Material Science: Potential monomer or additive for creating specialty polymers with unique properties.
• Process Chemistry: Used in route scouting and optimization for the scalable production of complex molecules.

Basic Information

Product Name	Pyrrolidine, 3,4-Difluoro-, Hydrochloride (1:1), (3S,4R)-Rel-
CAS No.	869481-94-7
Molecular Formula	C4H7F2N • HCl
Molecular Weight	139.56 g/mol (Free base: 103.10 g/mol)
Synonyms	(3S,4R)-3,4-Difluoropyrrolidine Hydrochloride; rel-(3S,4R)-3,4-Difluoropyrrolidine Hydrochloride; 3,4-Difluoropyrrolidine HCl (racemic mixture of enantiomers related to specified stereoisomer); 3,4-Difluoro-pyrrolidine hydrochloride; Pyrrolidine, 3,4-difluoro-, hydrochloride, (3S,4R)-rel-; 869481-94-7
EINECS	Contact for details

Quality Control

Every batch of (3S,4R)-rel-3,4-Difluoropyrrolidine Hydrochloride is manufactured under strict quality management systems. We employ advanced analytical techniques, including chiral HPLC, NMR, and LC-MS, to ensure identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing assay, enantiomeric excess, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to handle the material under a dry inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to ambient humidity during use. Recommended storage temperature: 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.