Description

Methyl 2-(5-Bromopyridin-2-Yl)-2-Methylpropanoate CAS NO 869349-03-1 is a high-purity, advanced pharmaceutical intermediate characterized by its brominated pyridine core and ester functionality. This compound is of critical importance for its role as a versatile building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in kinase inhibitor research. It is primarily needed by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in developing novel therapeutics for oncology and other disease areas.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug candidates, especially kinase inhibitors.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, leveraging its halogenated heterocyclic structure.
• Material Science: Serves as a monomer or precursor for functional polymers and liquid crystals.
• Organic Synthesis: Utilized in cross-coupling reactions (e.g., Suzuki, Stille) due to the reactive bromine substituent.
• Chemical Biology: Employed as a probe or linker in bioconjugation and proteomics research.
• Academic Research: A valuable reagent for methodological studies in synthetic organic chemistry.

Basic Information

Product Name	Methyl 2-(5-Bromopyridin-2-Yl)-2-Methylpropanoate
CAS No.	869349-03-1
Molecular Formula	C10H12BrNO2
Molecular Weight	258.11 g/mol
Synonyms	2-(5-Bromo-2-pyridinyl)-2-methylpropanoic acid methyl ester; Methyl 2-(5-bromopyridin-2-yl)-2-methylpropionate; 2-Methyl-2-(5-bromopyridin-2-yl)propanoic acid methyl ester; 869349-03-1; Methyl α,α-dimethyl-5-bromopicolinate; 5-Bromo-2-(2-methoxy-2-oxo-1,1-dimethylethyl)pyridine
EINECS	Contact for details

Quality Control

Our Methyl 2-(5-Bromopyridin-2-Yl)-2-Methylpropanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our production adheres to cGMP guidelines where applicable, ensuring consistency and reliability for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.