Description

1H-Pyrrolo[2,3-B]Pyridine, 4-Chloro-1-[(4-Methylphenyl)Sulfonyl]-3-(Trifluoromethyl)- is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound is critical for research and development in the pharmaceutical sector, where it serves as a key intermediate in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by medicinal chemists and process development scientists working in drug discovery for oncology, central nervous system (CNS) disorders, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and other targeted therapy research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its versatile pyrrolopyridine scaffold and functional groups.
• Process Chemistry Development: Serves as a key starting material (KSM) or advanced intermediate in the scale-up and optimization of API manufacturing routes.
• Agrochemical Research: Potential intermediate in the development of new herbicides or fungicides, leveraging its heterocyclic structure.
• Material Science Exploration: Investigated as a precursor for organic electronic materials or ligands in catalytic systems.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the life sciences industry.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 4-Chloro-1-[(4-Methylphenyl)Sulfonyl]-3-(Trifluoromethyl)-
CAS No.	869335-74-0
Molecular Formula	C15H10ClF3N2O2S
Molecular Weight	374.76 g/mol
Synonyms	4-Chloro-1-[(4-methylphenyl)sulfonyl]-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine; 4-Chloro-1-(p-tolylsulfonyl)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 4-chloro-1-[(4-methylphenyl)sulfonyl]-3-(trifluoromethyl)-; 4-Chloro-1-tosyl-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine; 869335-74-0; 4-Chloro-1-(4-methylbenzenesulfonyl)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our production of 1H-Pyrrolo[2,3-B]Pyridine, 4-Chloro-1-[(4-Methylphenyl)Sulfonyl]-3-(Trifluoromethyl)- adheres to stringent quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client requirements or internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended long-term storage at 2-8°C. The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to maximize stability and shelf-life.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.