Description

1H-Pyrrolo[2,3-B]Pyridine, 6-Chloro-4-Nitro-1-[[2-(Trimethylsilyl)Ethoxy]Methyl]- is a high-purity, advanced pharmaceutical intermediate featuring a protected heterocyclic core. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in oncology and kinase inhibitor research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for constructing novel drug candidates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of kinase inhibitors and other targeted cancer therapies.
• Organic Synthesis Reagent: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Research & Development: Essential material in academic and industrial labs for developing new heterocyclic compounds and exploring novel chemical spaces.
• Process Chemistry: Serves as a starting material or intermediate in the scale-up and commercial manufacturing of complex APIs.
• Custom Synthesis: Used by contract research and manufacturing organizations (CROs/CMOs) for client-specific molecule production.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 6-Chloro-4-Nitro-1-[[2-(Trimethylsilyl)Ethoxy]Methyl]-
CAS No.	869335-22-8
Molecular Formula	C13H18ClN3O3Si
Molecular Weight	327.84 g/mol
Synonyms	6-Chloro-4-nitro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine; 1-((2-(Trimethylsilyl)ethoxy)methyl)-6-chloro-4-nitro-1H-pyrrolo[2,3-b]pyridine; 6-Chloro-4-nitro-1-((2-(trimethylsilyl)ethoxy)methyl)-7-azaindole; SEM-Protected 6-Chloro-4-Nitro-7-Azaindole; 869335-22-8; 1H-Pyrrolo[2,3-b]pyridine, 6-chloro-4-nitro-1-[[2-(trimethylsilyl)ethoxy]methyl]-
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine, 6-Chloro-4-Nitro-1-[[2-(Trimethylsilyl)Ethoxy]Methyl]- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for each lot to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.