Description

1H-Pyrrolo[2,3-B]Pyridine, 4-Chloro-3-Methyl-1-[(4-Methylphenyl)Sulfonyl]- is a high-purity, advanced pharmaceutical intermediate characterized by its specific sulfonyl-substituted pyrrolopyridine core. This compound is critical for research and development in medicinal chemistry, serving as a versatile building block for constructing complex molecular architectures. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and bioactive compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new chemical entities.
• Kinase Inhibitor Development: The pyrrolopyridine scaffold is a privileged structure in the design of kinase inhibitors, making this intermediate valuable for targeted therapy research.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for the custom synthesis of complex molecules for client projects.
• Academic Research: Utilized in university and institutional laboratories for fundamental research in heterocyclic chemistry and drug discovery methodologies.
• Process Chemistry: Serves as a starting material or intermediate in scaling up synthetic routes from laboratory to pilot plant scale.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 4-Chloro-3-Methyl-1-[(4-Methylphenyl)Sulfonyl]-
CAS No.	869335-18-2
Molecular Formula	C15H13ClN2O2S
Molecular Weight	320.79 g/mol
Synonyms	4-Chloro-3-methyl-1-(4-methylphenyl)sulfonyl-1H-pyrrolo[2,3-b]pyridine; 1-(4-Methylbenzenesulfonyl)-4-chloro-3-methyl-1H-pyrrolo[2,3-b]pyridine; 4-Chloro-3-methyl-1-(p-tolylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1-(p-Toluenesulfonyl)-4-chloro-3-methyl-1H-pyrrolo[2,3-b]pyridine; 869335-18-2; 4-Chloro-3-methyl-1-tosyl-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 4-chloro-3-methyl-1-[(4-methylphenyl)sulfonyl]-
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine, 4-Chloro-3-Methyl-1-[(4-Methylphenyl)Sulfonyl]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent chemical identity, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, identity confirmation, and impurity profiles are provided with every shipment. Our quality commitment aligns with cGMP principles where applicable for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and stored in the original packaging away from direct light and moisture sources.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.