Description

tert-Butyl trans-4-Hydroxycyclohexanecarboxylate is a high-value, chiral building block and pharmaceutical intermediate of significant commercial interest. Its rigid cyclohexane ring with defined stereochemistry makes it a crucial synthon for constructing complex molecules with specific three-dimensional architectures. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and fine chemical industries for the development of active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of various therapeutic agents, particularly those targeting the central nervous system (CNS) and metabolic diseases.
• Asymmetric Synthesis: Utilized as a building block in stereoselective reactions to introduce the trans-4-hydroxycyclohexyl moiety into target molecules.
• Ligand and Catalyst Development: Serves as a starting material for creating novel chiral ligands and organocatalysts used in enantioselective transformations.
• Fine Chemical Production: Employed in the multi-step synthesis of complex fragrances, agrochemicals, and specialty polymers.
• Academic and R&D: Used in medicinal chemistry research for structure-activity relationship (SAR) studies and the discovery of new chemical entities.

Basic Information

Product Name	tert-Butyl trans-4-Hydroxycyclohexanecarboxylate
CAS No.	869193-57-7
Molecular Formula	C11H20O3
Molecular Weight	200.27 g/mol
Synonyms	trans-4-Hydroxycyclohexanecarboxylic acid tert-butyl ester; tert-Butyl (1r,4r)-4-hydroxycyclohexanecarboxylate; (1r,4r)-4-(tert-Butoxycarbonyl)cyclohexanol; trans-4-(tert-Butoxycarbonyl)cyclohexanol; Cyclohexanecarboxylic acid, 4-hydroxy-, 1,1-dimethylethyl ester, trans-; TBHCC; t-Butyl trans-4-hydroxycyclohexylcarboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl trans-4-Hydroxycyclohexanecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee (trans isomer)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.