Description

6-((Trimethylsilyl)Ethynyl)Pyridin-3-Amine is a high-value, functionalized pyridine derivative featuring a trimethylsilyl-protected ethynyl group, making it a versatile building block for advanced organic synthesis. This compound is particularly significant for its role as a key intermediate in the development of pharmaceuticals, agrochemicals, and functional materials. It is essential for researchers and manufacturers in medicinal chemistry, material science, and fine chemical production who require precise, high-purity intermediates for coupling reactions and molecular scaffold construction.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides, leveraging its pyridine core for biological activity.
• Material Science: Serves as a building block for organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) due to its conjugated ethynyl group.
• Cross-Coupling Reactions: An excellent substrate for Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions to create complex molecular architectures.
• Chemical Research: Employed in academic and industrial R&D for exploring new synthetic pathways and creating novel chemical entities.
• Ligand Synthesis: Used to prepare sophisticated ligands for catalysis in asymmetric synthesis and transition metal complexes.

Basic Information

Product Name	6-((Trimethylsilyl)Ethynyl)Pyridin-3-Amine
CAS No.	868736-61-2
Molecular Formula	C10H16N2Si
Molecular Weight	192.33 g/mol
Synonyms	3-Amino-6-((trimethylsilyl)ethynyl)pyridine; 5-Amino-2-((trimethylsilyl)ethynyl)pyridine; 6-(Trimethylsilylethynyl)pyridin-3-amine; 6-(2-Trimethylsilylethynyl)-3-pyridinamine; 6-Ethynyl-3-pyridinamine, trimethylsilyl derivative; 3-Pyridinamine, 6-[(trimethylsilyl)ethynyl]-; TMS-Ethynyl-3-aminopyridine
EINECS	Contact for details

Quality Control

Our 6-((Trimethylsilyl)Ethynyl)Pyridin-3-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.