Description

5,8,11,14,17,20-Hexaoxa-2-Azadocosanoic Acid, 22-Hydroxy-,9H-Fluoren-9-Ylmethyl Ester is a specialized, multifunctional PEG-based linker molecule featuring a carboxylic acid, a hydroxyl group, and a fluorenylmethyl (Fmoc) protecting group. This compound is engineered for high-value applications in bioconjugation and advanced material synthesis, offering precise control over molecular assembly. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for creating targeted drug delivery systems, diagnostic agents, and functional polymers.

Application

• Bioconjugation Linker: For attaching peptides, proteins, or other biomolecules to surfaces, nanoparticles, or drug carriers via its carboxylic acid and hydroxyl functionalities.
• Solid-Phase Peptide Synthesis (SPPS): The Fmoc-protected amine allows for its use as a building block or cleavable linker in automated peptide synthesis.
• Polymer Modification: Serves as a functional monomer or cross-linking agent to introduce hydrophilic PEG spacers and reactive sites into polymer backbones.
• Prodrug Synthesis: Used in the design and synthesis of prodrugs where controlled release or targeted delivery is required.
• Diagnostic Reagent Preparation: Facilitates the labeling of antibodies, enzymes, or other probes for use in immunoassays and imaging.
• Surface Functionalization: Applied to modify the surface properties of materials like silica, gold, or polymers to enhance biocompatibility and introduce specific chemical handles.
• Hydrogel Formation: Acts as a cross-linker or functional component in the creation of hydrogels for biomedical applications such as tissue engineering.
• Research Chemical: A key intermediate in organic and medicinal chemistry research for exploring new synthetic pathways and molecular architectures.

Basic Information

Product Name	5,8,11,14,17,20-Hexaoxa-2-Azadocosanoic Acid, 22-Hydroxy-,9H-Fluoren-9-Ylmethyl Ester
CAS No.	868594-44-9
Molecular Formula	C₃₃H₄₇NO₁₀
Molecular Weight	617.73 g/mol
Synonyms	Fmoc-NH-PEG6-CH2CH2COOH; Fmoc-8-amino-3,6-dioxaoctanoic Acid (extended PEG variant); 22-Hydroxy-5,8,11,14,17,20-hexaoxa-2-azadocosanoic acid 9H-fluoren-9-ylmethyl ester; N-α-Fmoc-8-amino-3,6-dioxaoctanoic acid (PEG6 analog); Fmoc-PEG6-acid; Fmoc-AEEA-PEG4-acid; Fmoc-N-amido-PEG6-acid; Heterobifunctional PEG linker, Fmoc- and COOH-terminated
EINECS	Contact for details

Quality Control

Every batch of our 5,8,11,14,17,20-Hexaoxa-2-Azadocosanoic Acid, 22-Hydroxy-,9H-Fluoren-9-Ylmethyl Ester is manufactured and tested under strict quality management systems. We ensure compliance with relevant standards for research and pharmaceutical intermediates. Comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, is performed to verify identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic nature, the container should be sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to prevent moisture absorption and degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Typical: 97-99%)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.