Description

(4-Bromophenyl)(2-Chloropyridin-4-Yl)Methanone is a high-purity, bifunctional aromatic ketone building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both bromo and chloro substituents on distinct aromatic rings, makes it a versatile precursor for constructing complex heterocyclic systems and pharmaceutical intermediates. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for applications such as Suzuki-Miyaura cross-coupling and nucleophilic aromatic substitution reactions.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and other small-molecule drug discovery programs.
• Agrochemical Research: Serves as a building block for novel herbicides, fungicides, and insecticides, leveraging its halogenated structure for further functionalization.
• Material Science Precursor: Used in the synthesis of organic ligands for metal-organic frameworks (MOFs) and functional polymers with tailored electronic properties.
• Cross-Coupling Reactions: The bromophenyl moiety is an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck), enabling the formation of biaryl structures.
• Nucleophilic Aromatic Substitution: The 2-chloropyridine group is reactive towards nitrogen and oxygen nucleophiles, facilitating pyridine ring diversification.
• Chemical Biology Probes: Utilized in the synthesis of tagged molecules and probes for studying biological pathways and target engagement.

Basic Information

Item	Detail
Product Name	(4-Bromophenyl)(2-Chloropyridin-4-Yl)Methanone
CAS No.	868390-64-1
Molecular Formula	C12H7BrClNO
Molecular Weight	296.55 g/mol
Synonyms	4-Bromo-2'-chlorobenzoylpyridine; 2-Chloro-4-(4-bromobenzoyl)pyridine; (4-Bromophenyl)(2-chloro-4-pyridinyl)methanone; 1-(4-Bromophenyl)-2-(2-chloropyridin-4-yl)ethanone (common misnomer); 4-Bromo-α-(2-chloro-4-pyridyl)acetophenone; 868390-64-1; (p-Bromophenyl)(2-chloro-4-pyridyl)ketone
EINECS	Contact for details

Quality Control

Our (4-Bromophenyl)(2-Chloropyridin-4-Yl)Methanone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and physical data. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.