Description

5-Fluoro-1-Triisopropylsilanyl-1H-Pyrrolo[2,3-B]Pyridine is a high-purity, protected heterocyclic building block essential for advanced organic synthesis. This compound matters as a key synthetic intermediate, offering a versatile scaffold for constructing complex molecules in pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially in oncology and CNS drug discovery.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The protected pyrrolopyridine core is amenable to various palladium-catalyzed reactions (e.g., Suzuki, Stille) for molecular diversification.
• Chemical Biology: Employed in the design and synthesis of molecular probes and tool compounds for biological target validation.
• Process Chemistry: Used in route scouting and optimization for the scalable production of complex molecules.

Basic Information

Product Name	5-Fluoro-1-Triisopropylsilanyl-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	868387-37-5
Molecular Formula	C17H27FN2Si
Molecular Weight	306.50 g/mol
Synonyms	1H-Pyrrolo[2,3-b]pyridine, 5-fluoro-1-[(1,1-dimethylethyl)dimethylsilyl]-; 5-Fluoro-1-[(1,1-dimethylethyl)dimethylsilyl]-1H-pyrrolo[2,3-b]pyridine; 5-Fluoro-1-(tert-butyldimethylsilyl)-1H-pyrrolo[2,3-b]pyridine; 5-Fluoro-1-TIPS-1H-pyrrolo[2,3-b]pyridine; 5-Fluoro-1-triisopropylsilyl-1H-pyrrolo[2,3-b]pyridine; TIPS-Protected 5-Fluoropyrrolopyridine; 868387-37-5
EINECS	Contact for details

Quality Control

Our 5-Fluoro-1-Triisopropylsilanyl-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light) and should be handled with appropriate precautions for strong acids/organic solvents. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.