Description

Methyl (1R,2S)-2-(tert-Butoxycarbonylamino)Cyclobutanecarboxylate is a high-purity, chiral cyclobutane derivative that serves as a critical building block in advanced organic synthesis. Its value lies in providing a stereochemically defined, protected amino acid framework essential for constructing complex molecular architectures. This intermediate is primarily needed by pharmaceutical R&D and process chemistry teams for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring constrained peptide mimetics and bioactive small molecules.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of protease inhibitors, kinase inhibitors, and other targeted therapeutics.
• Peptidomimetic Research: Core scaffold for constructing conformationally restricted peptide analogs to enhance metabolic stability and receptor selectivity.
• Medicinal Chemistry: Used in lead optimization and structure-activity relationship (SAR) studies to explore novel bioactive chemical space.
• Process Chemistry: Serves as a starting material or advanced intermediate in the scalable, GMP-compliant manufacturing of drug candidates.
• Chemical Biology: Useful for incorporating rigid, functionalized cyclobutane motifs into molecular probes and tool compounds.
• Asymmetric Synthesis: Employed in stereoselective transformations to introduce complex chirality in natural product synthesis and catalyst development.

Basic Information

Item	Details
Product Name	Methyl (1R,2S)-2-(tert-Butoxycarbonylamino)Cyclobutanecarboxylate
CAS No.	868364-62-9
Molecular Formula	C12H21NO4
Molecular Weight	243.30 g/mol
Synonyms	(1R,2S)-Methyl 2-((tert-butoxycarbonyl)amino)cyclobutanecarboxylate; (1R,2S)-Boc-Amino-cyclobutanecarboxylic acid methyl ester; Methyl (1R,2S)-2-(Boc-amino)cyclobutanecarboxylate; (1R,2S)-2-(Boc-Amino)cyclobutanecarboxylic Acid Methyl Ester; (1R,2S)-N-Boc-2-aminocyclobutanecarboxylic acid methyl ester; (1R,2S)-2-[(tert-Butoxycarbonyl)amino]cyclobutanecarboxylic acid methyl ester; trans-(1R,2S)-Methyl 2-(Boc-amino)cyclobutanecarboxylate
EINECS	Contact for details

Quality Control

Our Methyl (1R,2S)-2-(tert-Butoxycarbonylamino)Cyclobutanecarboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Products undergo rigorous analytical testing, including chiral HPLC and NMR, to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are available upon request to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.