Description

2-(5-Piperidin-4-Yl-4H-1,2,4-Triazol-3-Yl)Pyridine Dihydrochloride is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) intermediate with significant pharmacological research value. This compound is critical for the development of novel antiviral therapeutics, particularly in the fight against resistant HIV strains. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in advanced drug discovery and process development.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of next-generation non-nucleoside reverse transcriptase inhibitors (NNRTIs) for antiviral applications.
• Antiviral Drug Discovery: Serves as a core scaffold in medicinal chemistry programs targeting HIV-1 and other retroviruses.
• Biochemical Research: Used as a reference standard and active pharmaceutical ingredient (API) precursor in virology and enzymology studies.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and cGMP manufacturing for clinical trial material.
• Contract Manufacturing: Supplied to CDMOs for the production of bespoke intermediates under strict quality agreements.

Basic Information

Product Name	2-(5-Piperidin-4-Yl-4H-1,2,4-Triazol-3-Yl)Pyridine Dihydrochloride
CAS No.	868280-58-4
Molecular Formula	C12H16Cl2N6
Molecular Weight	315.20 g/mol
Synonyms	2-(5-(Piperidin-4-yl)-4H-1,2,4-triazol-3-yl)pyridine dihydrochloride; 2-[5-(4-Piperidinyl)-4H-1,2,4-triazol-3-yl]pyridine dihydrochloride; Pyridine, 2-[5-(4-piperidinyl)-1H-1,2,4-triazol-3-yl]-, dihydrochloride; NNRTI Intermediate; Rilpivirine Intermediate (related); 868280-58-4
EINECS	Contact for details

Quality Control

Our 2-(5-Piperidin-4-Yl-4H-1,2,4-Triazol-3-Yl)Pyridine Dihydrochloride is manufactured under a quality management system and undergoes rigorous analytical testing to ensure batch-to-batch consistency and high purity suitable for research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment. We can support development with specifications aligned with ICH guidelines for impurities and stability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.